St. Louis /seÉªnt ËˆluËÉªs/ ) is an independent city on the eastern border of Missouri, United States. With a population of 319,294, it was the 58th-largest U.S. city at the 2010 U.S. Census. The Metropolitan Statistical Area population of 2,812,896 is the 18th-largest in the country. The Greater St. Louis combined statistical area's population of 2,878,255 is the 16th-largest CSA in the country, the fourth-largest in the Midwest.
History of St. Louis, Missouri The area that would become St. Louis was a center of Native American Mississippian culture, which built numerous temple and residential earthwork mounds in the region, giving the city its nickname, the "Mound City". European exploration of the area began in 1673, when French explorers Louis Jolliet and Jacques Marquette traveled through the Mississippi River valley. Five years later, La Salle claimed the region for France, and the earliest settlements in the area were built in Illinois during the 1690s and early 1700s at Cahokia, Kaskaskia, and Fort de Chartres.